Molecular chaperones: The modular evolution of cellular networks
نویسندگان
چکیده
منابع مشابه
Molecular chaperones as regulatory elements of cellular networks.
Molecular chaperones help hundreds of signaling molecules to keep their activation-competent state, and regulate various signaling processes ranging from signaling at the plasma membrane to transcription. Besides these specific regulatory roles, recent studies have revealed that chaperones act as genetic buffers stabilizing the phenotypes of various cells and organisms. This may be related to t...
متن کاملMolecular chaperones, evolution and medicine
Protein folding has numerous steps, which need assistance in vivo. Molecular chaperones are required for many proteins to fold, or re-fold into native structures forming an ancient, primary system for ‘intracellular self-defense’. Molecular chaperones participate in the organization of the cytoarchitecture, were necessary for the development of modern enzymes and—by stabilizing the genome—for t...
متن کاملChaperones as parts of cellular networks.
The most important interactions between cellular molecules have a high affinity, are unique and specific, and require a network approach for a detailed description. Molecular chaperones usually have many first and second neighbors in protein-protein interaction networks and they play a prominent role in signaling and transcriptional regulatory networks of the cell. Chaperones may uncouple prote...
متن کاملMolecular chaperones: Pathways and networks
Some proteins synthesized by growing eukaryotic cells are transferred along unidirectional pathways of molecular chaperones until the risk of aggregation has decreased and they can be released safely. Mature proteins denatured by stress may instead be handled by chaperones acting in branched, reversible networks.
متن کاملMolecular chaperones--cellular machines for protein folding.
Proteins are linear polymers synthesized by ribosomes from activated amino acids. The product of this biosynthetic process is a polypeptide chain, which has to adopt the unique three-dimensional structure required for its function in the cell. In 1972, Christian Anfinsen was awarded the Nobel Prize for Chemistry for showing that this folding process is autonomous in that it does not require any...
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ژورنال
عنوان ژورنال: Journal of Biosciences
سال: 2007
ISSN: 0250-5991,0973-7138
DOI: 10.1007/s12038-007-0043-y